Sunday, October 13, 2019
Is Learning Invisible to the Learner? :: Education Teaching Learning Essays
Is Learning Invisible to the Learner? Think back to all the things that you learned during your childhood and see if you remember them? If you do remember them, think about how you learned them. Did you ever realize that the experiences that you encountered would still be with you today? Or did you even realize that you were learning from the company around you. Well, people who get a better understanding of how they learn and who they learn from can become better learners themselves. Maybe if you would have had a better understanding for how you learn and whom you learn from you would have been a better learner. Smith, Golub, and Gardner are three authors who address this issue. Smith is one author who says that we learn without realizing weââ¬â¢re learning. He believes that we learn by the company we keep. This kind of learning puts us in a category of belonging to a club. At the start of our childhood we start to develop an identity through the members of our club. How many times did you do something because of the actions of others? This is the type of thing that influences us in the way we learn. While growing up, I mainly stayed around one group of friends. I established an identity through these people and I felt comfortable around them. This group of friends was considered my club. This group of people influenced much of my action whether it was in a positive or negative way. But regardless of how I was being influenced, I was still learning something new. For example, there was once a cactus in my 5th grade classroom that I always wanted to touch. I wanted to touch it because I knew it was sharp and I wanted to see if it would prick me and make me bleed. Now I realize that would have been very dumb because of the action of one of my friends. Unfortunately he decided to touch the cactus for the same reason, only to find out that it had poisonous needles that caused his skin to break out in hives. Luckily I learned from his actions instead of making the same mistake. This person along with all the others around me taught me so many different things that I was never even aware of. Did I ever consider that I learned from them?
Saturday, October 12, 2019
Diary Entries for Juliet :: Papers
Diary Entries for Juliet Dear Diary, My time has come, I knew it would come soon, I am soon to be married. I don't know what to do or what to think. When I was told the news my life flashed before my eyes, I saw myself in a loveless marriage, sitting at home in old clothes, slaving over a hot stove all day and looking after the children, what kind of a future is that? Getting married is an honour, because it shows you are wanted and the older you are the less likely you are to get married and your parents will have to look after you. I don't want to disappoint my parents, but I truly feel marriage, at this stage in my life, is not what I want. I am not ready to make such a commitment. The man I am meant to marry I'm to meet at this party my father is throwing. I am supposed to like him, what happens if I don't? Even if I like him, I certainly don't want to marry him. My father, I think, will give me some say in the matter, after all it is my life and he is meant to love and respect me. My nanny is more like my mother, my mother and father weren't around much when I was growing up and I feel a really strong bond between the nanny and I and she will support me whatever I choose, if I get to choose. This party is going to be the worst yet, I'm not even bothered about what I'm going to wear. Also I can't enjoy myself because I know soon I could marry, possibly to someone who is not right for me. Come to think of it I know nothing about this man, how is the marriage supposed to last anyway? HELP! I can hear my mother calling, got to go. Juliet Dear Diary, Romeo, Romeo, I am in love with Romeo, not with the man my dad picked, Paris.
Friday, October 11, 2019
The Effects of Media on Teenagers
As a teen, I myself think itââ¬â¢s pretty safe to say that TV, as well as movies and other media, are some of our primary sources of information about sex and sexuality. Statistics estimate that the average teen will be exposed to around 15000 references to sex each year on TV. TV shows and movies make it seem normal for teenagers to have sex. And letââ¬â¢s be honest, it probably is. But the fact of the matter is the media has a whole lot of influence over the way we perceive sexuality, and actually a great deal of it comes from the music industry, especially through music videos. You try to think of one song thatââ¬â¢s been on MTV music channel, that hasnââ¬â¢t mentioned anything remotely to do with sex or a broken relationship. Now think of one music video youââ¬â¢ve watched on 4music channel that didnââ¬â¢t include one scrap of sexual imagery or expose and focus on a scantily clad female. Yeah, didnââ¬â¢t think you could. Whatââ¬â¢s worse is that a recent study of video games teenage boys regularly play found that the few female characters in those games are often highly sexualizedââ¬âwearing tight revealing clothing and having unrealistically large breasts, and unnaturally disfiguring small waists. Is this distorting the way guys view real women? Well, sorry for the wakeup call boys, but youââ¬â¢re in for a shocking discovery. Another study of network television commercials found that nearly one in 4 commercials includes some type of sexual attractiveness as a base for the message. What is going on with the world? Are we so unimaginative weââ¬â¢ve resorted to sexual attraction as a method to persuade people to buy shampoo? Is this nation as gullible to believe that ââ¬Ëwhen you buy this insanely expensive bottle of shampoo, youââ¬â¢ll automatically transform from your naught-over-average self into this booby-blonde bimbo who probably eats an average of 200 calories a dayââ¬â¢ really? Why donââ¬â¢t we just change it from ââ¬ËAdvertising Executivesââ¬â¢ to freaking ââ¬ËPornography Wholesaleââ¬â¢ and be done with it?! Which brings me to another point. Young girls were quoted as saying that they would prefer to have cancer, lose both their parents, or live through a nuclear holocaust than be fat. You might be thinking, ââ¬ËIs this a joke? ââ¬â¢ I really wish it was. Because take it from someone who has grown up with only one parent, being fat is the least of your worries. And this problem isnââ¬â¢t limited to just girls, oh no. Because the amount of males with eating disorders has in fact doubled over the past decade. Sorry lads, but youââ¬â¢re not faultless. On the other hand, nobody is. Even the media canââ¬â¢t hide from you that basic fact ââ¬â the new Rimmel girl, quite frankly, looks almost the double of a frogmouth catfish. Not that they donââ¬â¢t put up a good fight. Take one look at any middle-shelf magazine and youââ¬â¢ll see exactly what every single other woman in the country no doubt sees, ââ¬â todayââ¬â¢s airbrushed perception of the perfect beauty. The elementary trend in the media industry at present is to promote slim, almost unnaturally skinny womenââ¬â¢s bodies, and sell it out as the only way to be accepted as beautiful. Women, especially young women, take one look at magazines, TV programmes, movies and other media products and accept this falsified version of a human being, and distressingly of all, believe in it. These images are distinguished in the mind of young women as being a role model to follow, and aspire to be like. Unfortunately girls, attaining this emaciated look doesnââ¬â¢t come naturally (unless youââ¬â¢ve been blessed with an insanely high metabolism ââ¬â for which, I am extremely resentful), and inevitably leads to exercising some form of diet, excessive amounts of exercise or aberrant eating behaviours. In actual fact, the number of people with some form of eating disorder is triple the amount of people with AIDS. Two in five women have admitted that they were unhappy with their bodies, which means 40% of you reading this know exactly what Iââ¬â¢m talking about. The media does affect us, and there isnââ¬â¢t much we can do about that. What you can do, is stop comparing yourself to the cover models ââ¬â because theyââ¬â¢re not real women. Beauty is natural, not airbrushed, and natural is how you are in yourself ââ¬â not how you adapt yourself around an imageââ¬â¢s expectations.
Thursday, October 10, 2019
Medical Immunology
MEDICAL IMMUNOLOGY & SEROLOGY Terence L. Eday, RMT, MT(ASCPi), MPH College of Medical Technology / Medical Laboratory Science University of Perpetual Help System DALTA Historical Perspective â⬠¢ 1773, Voltaire reported on an ancient Chinese custom where dried and powdered small pox scabs were inhaled â⬠¢ 1798, Edward Anthony Jenner, Smallpox vaccination â⬠¢ 1862, Ernst Haekel, Recognition of phagocytosis 1877, Paul Erlich, recognition of mast cells Historical Perspective â⬠¢ 1879, Louis Pasteur, Attennuated chicken cholera vaccine development â⬠¢ 1883, Ellie Metchnikoff developed the cellular theory of immunity through phagocytosis; phagocytic theory; cellular theory of vaccination â⬠¢ 1885, Pasteur discovered therapeutic vaccination; first report of live ââ¬Å"attenuatedâ⬠vaccine for rabies Historical Perspective 1888, Pierre Roux & Alexander Yersin, Bacterial toxins (Yersinia pestis) â⬠¢ 1888, George Nuttall, Bactericidal action of blood â⬠¢ 1 890, Emil von Behring and Kitasata introduced passive immunization into modern medicine; humoral theory of immunity â⬠¢ 1891, Robert Koch demonstrated the cutaneous (delayed-type) hypersensitivity â⬠¢ 1894, Richard Pfeiffer, Bacteriolysis Historical Perspective (1 of 6 ) 1895, Jules Bordet, Complement and antibody activity in bacteriolysis â⬠¢ 1900, Paul Ehrlich, responsible for the antibody formation theory â⬠¢ 1901, Karl Landsteiner, A, B, and O â⬠¢ 1901-8, Carl Jensen & Leo Loeb, Transplantable tumors â⬠¢ 1902, Paul Portier & Charles Richet, Anaphylaxis Historical Perspective (1 of 6 ) â⬠¢ 1903, Nicolas Maurice Arthus, discovered the Arthus reaction of intermediate hypersensitivity â⬠¢ 1903, Almroth Wright and Stewart Douglas observed the humoral component, opsonin â⬠¢ 1906, Clemens von Pirquet, coined the word allergy â⬠¢ 1907, Svante Arrhenius, coined the term immunochemistryHistorical Perspective â⬠¢ 1910, Emil von Dungern, & Ludwik Hirszfeld, Inheritance of ABO blood groups â⬠¢ 1910, Peyton Rous, Viral immunology theory â⬠¢ 1914, Clarence Little, Genetics theory of tumor transplantation â⬠¢ 1915-20, Leonll Strong & Clarence Little, Inbred mouse strains Historical Perspective â⬠¢ 1917, Karl Landsteiner, Haptens â⬠¢ 1921, Carl Prausnitz & Heinz Kustner, Cutaneous reactions â⬠¢ 1924, L. Aschoff, Reticuloendothelial system â⬠¢ 1926, Loyd Felton & GH Bailey, Isolation of pure antibody preparation â⬠¢ 1938, John Marrack, Antigen-antibody binding hypothesis Historical Perspective 1936, Peter Gorer, Identification of the H2 antigen in mice â⬠¢ 1940, Karl Landsteiner & Alexander Weiner, Identification of the Rh Antigens â⬠¢ 1941, Albert Coons, Immunofluorescence technique â⬠¢ 1942, Jules Freund & Katherine McDermott, Adjuvants â⬠¢ 1942, Karl Landsteiner & Merill Chase, Cellular transfer of sensitivity in guinea pigs (anaphylaxis) Historical Perspective â⬠¢ 1944, Peter Medwar, Immunological hypothesis of allograft rejection â⬠¢ 1948, Astrid Fagraeus, Demonstration of antibody production in plasma B cells â⬠¢ 1948, George Snell, Congenic mouse lines â⬠¢ 1949, Macfarlane Burnet & Frank Fenner, Immunological tolerance hypothesisHistorical Perspective â⬠¢ 1950, Richard Gershon and K Kondo, Discovery of supressor T cells â⬠¢ 1952, Ogden and Bruton, discovery of agammaglobulinemia (antibody immunodeficiency) â⬠¢ 1953, Morton Simonsen and WJ Dempster, Graft-versus-host reaction â⬠¢ 1953, James Riley & Geoffrey West, Discovery of histamine in mast cells Historical Perspective â⬠¢ 1953, Rupert Billingham, Leslie Brent, Peter Medwar, & Milan Hasek, Immunological tolerance hypothesis â⬠¢ 1955-1959, Niels Jerne, David Talmage, Macfarlane Burnet, Clonal Selection Theory â⬠¢ 1957, Ernest Witebsky et all. Induction of autoimmunity in animals â⬠¢ 1957, Alik Isaacs & Jean Lindemann, Discovery of interferon (cytokine) Hi storical Perspective â⬠¢ 1958-62, Jean Dausset et al. , Human leukocyte antigens â⬠¢ 1959-62, Rodney Porter et al. , Discovery of antibody structure â⬠¢ 1959, James Gowans, Lympocyte circulation â⬠¢ 1961-62, Jaques Miller et al. , Discovery of thymus involvement in cellular immunity â⬠¢ 1961-62, Noel Warner et al. , Disctinction of cellular and humoral immune response Historical Perspective â⬠¢ 1963, Jacques Oudin et al. Antibody isotypes â⬠¢ 1964-68, Anthony Davis et al. , T and B cell cooperation in immune response â⬠¢ 1965, Thomas Tomasi et al. , Secretory immunoglobulin antibodies â⬠¢ 1967, Kimishige Ishizaka et al. , Identification of IgE as the reaginic antibody Historical Perspective â⬠¢ 1971, Donald Bailey, Recombinant inbred mouse strains â⬠¢ 1972, Gerald M. Edelman & Rodney Porter, Identification of antibody molecule â⬠¢ 1974, Rolf Zinkernagel & Peter Doherty, MHC restriction â⬠¢ 1975, Kohler and Milstein, First monoclona l antibodies used in genetic analysisHistorical Perspective â⬠¢ 1984, Robert Good, Failed treatment of severe combined immunodeficiency (SCID, David the bubble boy) by bone marrow grafting â⬠¢ 1985, Tonegawa, Hood et al. , Identification of immunoglobulin genes â⬠¢ 1985-1987, Leroy Hood et al. , Identification of genes for the T cell receptor â⬠¢ 1986, Monoclonal hepatitis B vaccine Historical Perspective â⬠¢ 1986, Mosmann, Th1 versus Th2 model of T-helper-cell function â⬠¢ 1990, Yamamoto et al. Molecular differences between the genes for blood groups O and A and between those for A and B â⬠¢ 1990, NIH team, Gene therapy for SCID using cultured T cells â⬠¢ 1993, NIH team, Treatment of SCID using genetically altered umbilical cord cells Historical Perspective â⬠¢ 1996-1998, Identification of toll-like receptors â⬠¢ 2001, FOXP3, the gene directing regulatory-T-cell development â⬠¢ 2005, Frazer, Development of human papilloma-virus vaccine Th e IMMUNE SYTEM What is Immunology? â⬠¢ Study of the molecules, cells, organs, and systems responsible for the recognition and disposal of foreign (nonself) material â⬠¢ â⬠¦ ow body components respond and interact â⬠¢ â⬠¦desirable and undesirable consequences of immune interactions â⬠¢ â⬠¦ways in which the immune system can be advantageously manipulated to protect against or treat disease What is Immunity? â⬠¢ Latin word ââ¬Å"immunitasâ⬠, freedom from â⬠¢ It refers to all mechanisms used by the body as protection against environmental agents that are foreign to the body. â⬠¢ Can be either natural (innate or inborn) or acquired (adaptive) Function of the Immune System â⬠¢ Recognize ââ¬Å"selfâ⬠from ââ¬Å"nonselfâ⬠â⬠¢ Defend the body against nonself Physiologic function is to prevent infection and to eradicate established infections (sterilizing immunity) Key Characteristics of the Immune System â⬠¢ Innate immunit y â⬠¢ Primary response â⬠¢ Secondary response and immunologic memory â⬠¢ Immune response is highly specific â⬠¢ Immune system is tolerant of self-antigens â⬠¢ Immune responses against self-antigens can result in autoimmune diseases â⬠¢ Immune responses against infectious agents do not always lead to elimination of the pathogen (HIV/AIDS) Major Principles of Immunity (immune response): Elimination of many microbial agents through the nonspecific protective mechanisms of the innate immune system. â⬠¢ Cues from the innate immune system inform the cells of the adaptive immune system as to whether it is appropriate to make a response and what type of response to make. Major Principles of Immunity (immune response): â⬠¢ Cells of the adaptive immune system display exquisitely specific recognition of foreign antigens and mobilize potent mechanisms for elimination of microbes bearing such antigens. The immune system displays memory of its previous responses. à ¢â¬ ¢ Tolerance of self-antigens. Cells of the Immune System â⬠¢ Lymphocytes ââ¬â occupy the central stage; determines the specificity of immunity â⬠¢ Dendritic cells (DCs) & Langerhan cells â⬠¢ Monocyte/macrophages â⬠¢ Natural killer (NK) cells â⬠¢ Neutrophils â⬠¢ Mast cells & Basophils â⬠¢ Eosinophils â⬠¢ Epithelial and stromal cells ââ¬â provides anatomic environment (secretion of critical factors that regulate migration, growth and homeostasis) Lymphoid Tissues and Organs Primary Lymphoid Organs Sites where pre-B and pre-T lymphocytes mature into naive T and B cells in the absence of foreign antigen; â⬠¢ Fetal Liver, Adult bone marrow, and thymus The INNATE IMMUNE SYTEM INNATE IMMUNE SYSTEM â⬠¢ relies on germ line-encoded receptors to detect a limited set of microbial structures that are uniquely associated with microbial infection â⬠¢ not a function of a single defined physiologic system; rather, it is a product of multiple a nd diverse defense mechanisms Modules of the Innate Immune System â⬠¢ Surface epithelium The phagocyte system ââ¬â critical for the defense against both intracellular and extracellular bacteria as well as fungal pathogens; aided by opsonins â⬠¢ Acute phase response and complement ââ¬â variety of secreted proteins that function in the circulation and in tissue fluids; secreted by the hepatocytes in response to the inflammatory cytokines IL1 and IL-6 Modules of the Innate Immune System â⬠¢ Natural killer (NK) cells are specialized in the elimination of infected host cells and in aiding defense against viral and other intracellular infections through production of cytokines(IFN-? ; regulated by type I interferons (IFN-? /? ) â⬠¢ Mast cells, eosinophils, and basophils are specialized in defense against multicellular parasites, such as helminthes; regulated by several cytokines, including IL-4, IL-5, IL-9, and IL-13 Strategies of Innate Immune Recognition 1. Recog nition of microbial nonself ââ¬â referred to as pattern recognition, based on the recognition of molecular structures that are unique to microorganisms and not produced by the host 2.Recognition of missing self ââ¬â based on the recognition of molecules expressed only on normal, uninfected cells of the host Targets of Innate Immune Recognition â⬠¢ PAMPs (pathogen-associated molecular patterns) ââ¬â molecular structures produced by microbial pathogens, but not by the host organism â⬠¢ PRRs (pattern recognition receptors) ââ¬â receptors of the innate immune system and represents targets of the innate immune system Targets of Innate Immune Recognition Examples of PAMPs include: (1) LPS of gram-negative bacteria (2) LTA of gram-positive bacteria (3) Peptidoglycans (4) Lipoproteins of bacteria (cell wall) (5) Lipoarabinomannan of mycobacteria (6) dsRNA produced by virus during the infection cycle (7) ? -glucans and mannans found in fungal cell wall Receptors of th e Innate Immune System â⬠¢ Broad categories of PRRs: (1) PRRs that signal the presence of infection; expressed on the cell surface or intracellularly Categories of gene products: a. proteins and peptides that have direct antimicrobial effector functions (antimicrobial peptides and lysozyme) b. nflammatory cytokines and chemokines (TNF, IL-1, IL-8) c. gene products that control activation of the adaptive immune response (MHC, CD80/CD86, IL-12) Receptors of the Innate Immune System â⬠¢ Broad categories of PRRs: (2) Phagocytic (or endocytic) PRRs; expressed on the surface of macrophages, neutrophils, and dendritic cells(DCs) (3) Secreted PRRs (mannan-binding lectin and peptidoglycan-recognition proteins Function: a. activate complement b. opsonize microbials cells to facilitate their phagocytosis c. ccessory proteins for PAMP recognition by transmembrane receptors (TLR) Receptors of the Innate Immune System â⬠¢ Toll-like Receptors ââ¬â comprise a family of type 1 transm embrane receptors characterized by leucine rich repeats (LRRs) in the extracellular portion and an intracellular TIR (Toll/IL-1 receptor) domain; grouped into two classes: (1) TLRs 1, 2, 4, 5, and 6 are expressed on the plasma membrane and detect bacterial and fungal cell wall components; (2) TLRs 3, 7, and 9 are expressed in endosomal compartments and recognize viral nucleic acidsToll-like receptor 4 (TLR4) â⬠¢ expressed predominantly in the cells of the immune system, including macrophages, DC, neutrophils, mast cells, and B cells â⬠¢ also expressed on endothelial cells, fibroblasts, surface epithelial cells, and muscle cell â⬠¢ Signal transducing receptor for LPS, heat sensitive protein associated with the cell walls of MTB â⬠¢ Together with CD14 shown to mediate responsiveness to the fusion (F) protein of RSVToll-like receptor 2 (TLR2) â⬠¢ Involved in recognition of LTA and peptidoglycan from gram-positive bacteria, bacterial lipoproteins, mycoplasma lipoprot ein, mycobacterial lipoarabinomannan, a phenol-soluble modulin from S. epidermidis, zymosan of yeast cell walls, and lipoglycosylphosphotidylinositol T. cruzi â⬠¢ Also shown to recognize two kinds of atypical LPS: L. interrogans and Porphyromonas gingivitis Toll-like receptor 3 (TLR3) Receptor for dsRNA â⬠¢ Can mediate responses to poly(IC) â⬠¢ Expressed on DCs, macrophages, and surface epithelial cells, including instestinal epithelium â⬠¢ Also expressed in CD8+ DCs Toll-like receptor 7 (TLR7) â⬠¢ Involved in viral recognition and both detect nucleic acids together with TLR9 â⬠¢ Recognizes viral ssRNA (derived from RNA viruses); TLR9 (unmethylated DNA derived from DNA viruses) â⬠¢ Expressed primarily on plasmacytoid dendritic cells â⬠¢ Activated by small antiviral compunds, e. g. imiquinoid â⬠¢TLR7-mediated recognition takes place inside the late lysosomes Toll-like receptor 9 (TLR9) â⬠¢ Involved in the antiviral host defense; especially on r ecognition of DNA viruses (HSV) â⬠¢ Expressed in type-I INF-producing plasmacytoid DCs Phagocytic Receptors â⬠¢ Scavenger receptors ââ¬â cell-surface glycoproteins that are defined by their ability to bind to modified LDL â⬠¢ Macrophage Mannose Receptor (MR) ââ¬â type I transmembrane protein expressed primarily in macrophages; involved in phagocytosis of bacterial (MTB, P. eruginosa, K. pneumonia), fungal (S. cerevisae, C. albicans), and protozoan pathogens (P. carinii) Cells of the Innate Immune System â⬠¢ Macrophages ââ¬â most central and essential functions and have multiple roles in host defense (e. i. ââ¬Å"housekeeping functionsâ⬠); in red pulp of the spleen, it phagocytose and remove from circulation senescent RBCs â⬠¢ Neutrophils â⬠¢ Mast Cells ââ¬â best known effectors of allergic response; protective role is by rapid production of TNF-? nd leukotriene B4 (neutrophil recruitement) Cells of the Innate Immune System â⬠¢ Eosino phils ââ¬â found primarily in the respiratory, intestinal, and genitourinary tracts; contains cationic effector proteins toxic to parasitic worms; poor phagocytes â⬠¢ Dendritic Cells ââ¬â immature DCs reside in peripheral tissues and are highly active in macropinocytosis and receptor-mediated endocytosis; expresses PRRs and TLRs; have roles in the initiation of adaptive immune response Cells of the Innate Immune System Suface Epithelium ââ¬â lines the mucosal surfaces of the intestinal, respiratory, and genitourinary tracts provide an important physical barrier The Effector Mechanisms of the Innate Immune System The Major Categories of Antimicrobial Effector Enzymes that hydrolyze components of microbial cell walls Antimicrobial proteins and petides that disrupt the integrity of microbial cell walls â⬠¢ Lysozyme â⬠¢ Chitinases â⬠¢ Phospholipase A2 â⬠¢ â⬠¢ â⬠¢ â⬠¢ â⬠¢ BPI Defensins Cathelicidins Complement Eosinophil cationic protein Mi crobicidal serine proteasesProteins that sequester iron and zinc Enzymes that generate toxic oxygen and nitrogen derivatives â⬠¢ Seprocidins â⬠¢ Lactoferrin â⬠¢ NRAMP â⬠¢ calprotein â⬠¢ Phagocytic oxidase â⬠¢ Nitric oxide synthase â⬠¢ myeloperoxidase The Effector Mechanisms of the Innate Immune System â⬠¢ Lysozyme ââ¬â a. k. a. muramidase; degrades the peptidoglycan of some gram(+) bacteria; highly concentrated in secretions such as tears and saliva â⬠¢ Chitinases ââ¬â enzymes that degrade chitin; secreted by activated macrophages and presumably play a role in antifungal defenseThe Effector Mechanisms of the Innate Immune System â⬠¢ Defensins ââ¬â cationic peptides with a broad spectrum of antimicrobial activities against gram(+) and gram(-) bacteria, fungi, parasites, and some envelope viruses; kill microorganisms by forming pores in the membranes; divided into ? ââ¬â and ? defensins â⬠¢ ? -defensins ââ¬â presynthesize d and stored in granules of neutrophils and Paneth cells of the small intestine â⬠¢ ? -defensins ââ¬â produced by epithelial cells and not stored in cytoplasmic granulesThe Effector Mechanisms of the Innate Immune System â⬠¢ Cathelicidins ââ¬â active against gram(+) and gram(-) bacteria and fungi; produced in neutrophils and stored as inactive proproteins in the secondary granules â⬠¢ Serprocedins ââ¬â comprise a family of cationic serine proteases with antimicrobial activity (neutrophil elastase, proteinase 3, cathepsin G, and azurocidin); exert its antimicrobial activity by either perturbation of microbial membranes or by proteolysisThe Effector Mechanisms of the Innate Immune System â⬠¢ Lactoferrin, NRAMP, and Calprotectin ââ¬â antimicrobial activities are due to the ability to sequester iron and zinc â⬠¢ Lactoferrin ââ¬â found in the secondary granules of neutrophils, in epithelial secretions (e. i. breast milk), in the intestinal epitheli um of infants, and in airway fluids; bacteriostatic (iron sequestration) and bacteriocidal (perturbation of microbial membranes) The Effector Mechanisms of the Innate Immune System NRAMP (natural resistance-associated macrophage protein) ââ¬â integral membrane protein that functions as an ion pump in the phagocytic vacuoles of macrophage and neutrophils â⬠¢ Calprotectin ââ¬â member of the family of calciumbinding proteins; microbial activity is by chelation and sequestration of zinc ion ACUTE PHASE REACTANTS â⬠¢ Soluble factors which are normal constituents that increase or decrease rapidly as produ â⬠¢ Not a function of a single defined physiologic system; rather, it is a product of multiple and diverse defense mechanisms
Wednesday, October 9, 2019
Managing organizational design and change Essay
Managing organizational design and change - Essay Example Persons must always come together to form an organization. A workable system and structure set up by more than two people forms an organization. (Fleming, 1989) describes it as a process of identifying and putting together the work to be performed, through definition and delegation of authority and responsibility, while establishing a relationship for the sole duty of ensuring that people work most effectively together in achieving set objectives. With systems and structures an organization is formed. This is by setting up of policies, rules, laws and chain management to run the whole set up structure. When a chain of management is put in place it is tasked with implementation of the set policies and rules. Policies form a critical phase in the running of the company. Leadership also forms a critical part in the running of an organization. With good and well governed leadership an organization is bound to excel and meet its targets and objectives. Lack of leadership and set policies and targets and organization will fail. This is an indication that an organisation is a group of people who have come together to work towards achieving a common goal guided by a given leadership. People with the same ideals, goals, and targets come together to form an organisation. The organisation is therefore tasked with the duty of achieving the set goals and target that have been made by various individuals. The leadership and management structure of any organisation is tasked with the duty of laying up structures and polices which ensures that an organisation is well run and organized. Organizations therefore implement the set policies and rules to ensure that their objectives are met. Organizations are formed to implement the policies and targets set up by the people who run it. Organizations can never be all the same. This is due to the varied nature of objectives of each organization. Depending on its objectives one organization will be
Tuesday, October 8, 2019
Profiles of an Effective Teacher Essay Example | Topics and Well Written Essays - 750 words
Profiles of an Effective Teacher - Essay Example In addition, it is the role of the school principles to hire reliable teachers with all the qualities of effectiveness. From the research effective teaching is described as a practice used to cultivate learning skills, create motivation, and instill knowledge to students. Skills and competencies of an effective teacher could be demonstrated when teaching in class, planning their lessons, modes of motivating students in classes among others. However, to improve the level of effectiveness of the teachers, principals should play a big role by devising various activities that could assist in guiding the teachers. The principal should supervise the teaching practices and evaluate the progress of the teachers to find whether they are on the right track towards effectiveness. The principals should come up with the ways to reward effective teachers and also creating guidelines that can assist the teachers to develop their skills and competencies. To improve the achievement of schools, principals should create strategies that could impart positive changes in the performance progress of both the teachers and students alike. The principals should adopt five domains implemented by Marzano (2013). Firstly, the principals and the teachers should develop data the focuses on the improvement of the studentsââ¬â¢ performance both at school and outside the school. Secondly, the teachers and principals should improve the existing instructions continuously that seem to pull back the performance of the school. Thirdly, the school should have a definite and reliable curriculum based on effective teaching and learning practices. Fourth, cooperation and collaboration among the teachers, principals, parents, and students should be put in place in the schoolsââ¬â¢ virtues.
Monday, October 7, 2019
Marketing Plan Essay Example | Topics and Well Written Essays - 750 words - 7
Marketing Plan - Essay Example In the contemporary world, it is evident that people are increasingly becoming aware of the importance of healthy products. In line with this, it is crucial for companies to ensure that they launched products that were healthy for this important segment of the population. In line with this, Rejuvenate juice seeks to meet the needs of this health-conscious client baseà since the juice is manufactured using natural products. Gitman and McDaniel noted the importance of a product strategy ââ¬Å"in choosing a brand name, packaging, colors, a warranty, and a service programâ⬠(295). It is crucial to point out that the brand name of this product is Rejuvenate, which implies that the product uplifts an individualà in an energetic way. Importantly, the ingredients for the juice will be mango, apple, pineapple, orange pulp, or a mixture of these fruits. In this case, fruits contain vitamins and proteins that provide an individual with the required energy besides the fruits being heal thy and in their natural form. In addition, other ingredients will include beta-carotene, citric acid, stabilizer, sugar, artificial flavors, and preservatives. On the other hand, the packaging and colors of the product will be attractive and take an energetic theme, which will be synonymous with the juice. In addition, the juice will come in packages of 500ml and 1l. Gitman and McDaniel noted, ââ¬Å"A special introductory price is used to get people to try a new product in a geographic areaâ⬠(295). In line with this, it is important for the company to set an introductory price that does not aim at earning profits in the initial short-term stage ofà introducing theà product. In this regard, the product will be available for an introductory price of $3 for a 500ml package while a 1l package will retail at $5. In this case, the pricing seeks to have many early adopters sample the product before adjusting the price of the product after determining whether the product will
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